Harmonization of Reference Intervals Working Group
CSCC Working Group on Harmonization of Reference Intervals
MISSION:
Establish evidence-based harmonized/common reference intervals (hRIs) and support their implementation in laboratories across Canada.
General Activities:
There is significant and unwarranted variation in reference intervals used by laboratories for assays with established analytical traceability. The CSCC Working Group on Reference Interval Harmonization (hRI-WG) aims to establish harmonized reference intervals for laboratory tests and support implementation. Key activities include:
- Development of a novel comprehensive approach for hRI establishment and application to 16 initial candidate analytes (expanded analyses planned)
- Development of tools for implementation of hRI recommendations in Canadian laboratories, including:
- Town hall/webinar series
- Educational resources
- Verification and flagging tools
Additional subcommittees also aim to harmonize interpretation of test results in specialized settings, including:
- Harmonization of Lipid Reporting in Adults and Pediatrics
- Harmonization of CSF Analysis for Investigation of Multiple Sclerosis
If interested in participating, please contact co-chairs Dr. Khosrow Adeli and Christine Collier.
Co-Chairs: |
Khosrow Adeli and Christine Collier |
Members: |
Dana Bailey Cynthia BalionDaniel Beriault George Cembrowski Victoria Higgins Benjamin Jung Zahraa Mohammed Ali Karina Rodriguez-Capote David Seccombe Jennifer Taher Albert Tsui Allison Venner Nicole White-Al Habeeb Julia Stemp |
Post-Doctoral and Graduate Student Members: |
Mary Kathryn Bohn |
CSCC Head Office Support: |
Erica Lattimore |
CSCC members on CSCChRI-L: |
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Industry Partner Representatives: |
Christina Fabbro (Abbott) Joe Bottos (Beckman) Maria Patru (OCD – Rochester, NY) Guy Turcotte (Roche) Matthew Coughlin (Siemens) Waihao Tang (Alexion) |
Representatives to Other Societies: |
K Adeli (AACC, IFCC) D Seccombe (AACC) J Macri (IFCC) Isolde Seiden-Long (ISO) Berna Aslan (IQMH) Karen Scraba (BD) |
Other Associations and Collaborators: |
Russell Price (President, Ontario Association of Pathologists –Barrie) Graham Jones (Australia) Lina Santaguida (Epidemiologist (methodology), McMaster) Qing Fan (LifeLabs) |
Recent Publications:
Main hRI WG:
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(as published in Journal of Laboratory Medicine, Volume 45, Pages 79-85 (April 2021)) |
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Lipid Reporting Subcommittee:
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Practice Updates:
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Includes published recommendations by CSCC hRI WG on lipid reporting in adults and additional resources (i.e., NIH LDL-C equation Implementation toolkit):
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