February 2, 2023: Diagnostic performance of neural antibody testing for autoimmune encephalitis

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Speaker:

Adrian Budhram. Assistant Professor of Neurology, Assistant Professor of Pathology and Laboratory Medicine. Western University.

Dr. Adrian Budhram obtained his medical degree from McMaster University, followed by residency training in neurology at Western University. He then went on to complete fellowship training in Autoimmune Neurology at the Mayo Clinic in Rochester, Minnesota. He has expertise in both the laboratory diagnosis and clinical management of patients with autoimmune neurological diseases. Dr. Budhram facilitated the launch of comprehensive neural antibody testing for autoimmune encephalitis, as well as the Autoimmune Neurology clinic at London Health Sciences Centre.

Overview:

Neural antibodies serve as helpful diagnostic biomarkers of autoimmune encephalitis, a potentially devastating yet treatable neurologic disease. As accessibility to neural antibody testing has increased, so too have evaluations of test diagnostic performance. We herein discuss the clinical sensitivity, specificity and predictive value of neural antibody testing for autoimmune encephalitis, with the aim of improving test implementation and interpretation in clinical practice.

Objectives:

At the end of this activity, participants will be able to:

  1. Describe clinical sensitivity, specificity and predictive value of diagnostic testing
  2. Discuss key considerations of these diagnostic test measures pertaining to neural antibody testing for autoimmune encephalitis
  3. Highlight ways to optimize the diagnostic performance of neural antibody testing for autoimmune encephalitis in clinical practice