| Speaker: | Dr. Peter Kavsak is a Professor in the Department of Pathology and Molecular Medicine at McMaster University and a clinical biochemist with the Hamilton Regional Laboratory Medicine Program. Internationally recognized for his expertise in cardiac biomarkers and laboratory medicine, his research has significantly advanced the clinical use of high-sensitivity cardiac troponin testing for the diagnosis and management of myocardial infarction. Dr. Kavsak has authored more than 240 peer-reviewed publications and has contributed to national and international guidance documents in cardiovascular diagnostics. He is a Fellow of the Canadian Academy of Clinical Biochemistry, the AACC Academy, and the Canadian Cardiovascular Society. In this CSCC educational roundtable/webinar, Dr. Kavsak will discuss analytical precision challenges of high-sensitivity cardiac troponin assays at the female 99th percentile and the implications for equitable and accurate patient care, drawing on findings from the CODE-MI Trial. |
| Overview: | The presentation will outline important findings from an analytical sub-study that was performed within the CODE-MI trial. The CODE-MI trial [hs-cTn – Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI)] was a multicenter, stepped-wedge, cluster-randomized trial that occurred across Canada from 2020 to 2025 (ClinicalTrials.gov ID NCT03819894) with the analytical sub-study occurring midway through the trial. New quality parameters established for the high-sensitivity cardiac troponin assays will be discussed and the presentation will highlight how collaboration with emergency medicine, cardiology and laboratory medicine can lead to novel approaches when using these assays. |
| Learning Objectives: | At the conclusion of this session, participants will be able to: 1. Define quality parameters that can be used for high-sensitivity cardiac troponin 2. List different analytical criteria that can be used with high-sensitivity cardiac troponin assays in the emergency setting and identify pros and cons with the listed criteria. |