hRI Working Group Lipid Subcommittee

The Lipids Subcommittee was formed in 2018 with the goal of establishing recommendations for laboratory reporting of lipid tests in pediatric and adult patients to align with Canadian clinical guidelines.

• Chairs: Victoria Higgins, Nicole White-Al Habeeb
• Members:
  • Khosrow Adeli
  • Daniel Beriault
  • Christine Collier
  • Dana Nyholt
  • Allison Venner

PUBLICATIONS
 
July 2024
Canadian Society of Clinical Chemists Harmonized Pediatric Lipid Reporting Recommendations for Clinical Laboratories
Higgins V, White-Al Habeeb NMA, Bailey D, Beriault DR, Blasutig IM, Collier CP, Venner AA, Adeli K; Canadian Society of Clinical Chemists Working Group on Reference Interval Harmonization. Canadian Society of Clinical Chemists Harmonized Pediatric Lipid Reporting Recommendations for Clinical Laboratories. Can J Cardiol. 2024 Jul;40(7):1183-1197. doi: 10.1016/j.cjca.2024.01.023. Epub 2024 Feb 8. PMID: 38336003.
https://pubmed.ncbi.nlm.nih.gov/38336003/
This article presented the work of the hRI lipid subcommittee on harmonizing pediatric lipid reporting across Canadian clinical laboratories. The 2022 Canadian Cardiovascular Society (CCS)/ Canadian Pediatric Cardiology Association (CPCA) clinical practice update along with the 2011 National Heart, Lung, and Blood Institute integrated guidelines, and new data analysis (CALIPER and retrospective patient data from large community laboratories) were used to develop 5 key recommendations. These recommendations included, 1) offering non-fasting and fasting lipid testing; 2) offering a lipid panel including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and triglycerides, with apolipoprotein B and lipoprotein(a) available as individually orderable tests; 3) flagging total cholesterol, LDL-C, and non-HDL-C results ≥ 95th percentile, and HDL-C results < 10th percentile, and flagging apolipoprotein B and non-fasting triglyceride results ≥ 95th percentile on the basis of CALIPER; 4) implementing interpretive comments listed in the current report; and 5) implementing the National Institutes of Health LDL-C equation. The hRI subcommittee aims to support clinical laboratories to implement these recommendations using knowledge translation strategies.
 
Aug 2022
Canadian Society of Clinical Chemists Harmonized Clinical Laboratory Lipid Reporting Recommendations on the Basis of the 2021 Canadian Cardiovascular Society Lipid Guidelines
White-Al Habeeb NMA, Higgins V, Venner AA, Bailey D, Beriault DR, Collier C, Adeli K; Canadian Society of Clinical Chemists Working Group on Reference Interval Harmonization. Canadian Society of Clinical Chemists Harmonized Clinical Laboratory Lipid Reporting Recommendations on the Basis of the 2021 Canadian Cardiovascular Society Lipid Guidelines. Can J Cardiol. 2022 Aug;38(8):1180-1188. doi: 10.1016/j.cjca.2022.03.019. Epub 2022 Apr 1. PMID: 35378262.
https://pubmed.ncbi.nlm.nih.gov/35378262/
This article presented the work of the hRI lipid subcommittee tasked with developing harmonized lipid reporting recommendations based on the 2021 CCS guidelines. Six recommendations for laboratory reporting lipid parameters were made in this position statement, including the implementation of the new National Institutes of Health for calculating low-density lipoprotein cholesterol, and the offering of lipoprotein (a), either as an in-house or send-out test. The proposed recommendations were critically reviewed by 30 laboratory and clinical experts across Canada. Feedback and consensus decisions were then incorporated into the 2021 harmonized lipid reporting recommendations. Along with the recommendations, a harmonized lipid reporting format with interpretive comments based on guideline decision thresholds was also developed to bridge the gap between clinical guidelines and laboratory reporting with the aim of improving cardiovascular risk assessment.
 
Jun 2021
A Snapshot of Lipid-Reporting Practices in Canadian Clinical Laboratories: An Urgent Need for Harmonisation
Higgins V, White-Al Habeeb N, Venner AA, Bailey D, Collier C, Adeli K; Higgins V, White-Al Habeeb N, Venner AA, Bailey D, Collier C, Adeli K. A Snapshot of Lipid-Reporting Practices in Canadian Clinical Laboratories: An Urgent Need for Harmonisation. Can J Cardiol. 2021 Jun;37(6):933-937. doi: 10.1016/j.cjca.2021.03.018. Epub 2021 Mar 26. PMID: 33775880.
https://pubmed.ncbi.nlm.nih.gov/33775880/
This article presented the work of the hRI lipid subcommittee as a first step towards establishing harmonized lipid reporting recommendations. The hRI lipid subcommittee surveys Canadian laboratories on adult lipid reporting practices, including the parameters used for lipid results, interpretative comments, and the handling of nonfasting lipid results. There was representation from 101 laboratories, 9 Canadian provinces, and 5 testing platforms. It found significant variability in the upper and lower limits for lipid parameters and their referenced sources. While 86% of laboratories report nonfasting lipids, methods for documenting fasting status varied. Additionally, 36% of laboratories expressed interest in implementing a harmonized lipid report. The findings highlight the need for consistent lipid reporting across Canada to enhance clinical decision-making and align with current Canadian guidelines.
 
 
PRESENTATIONS
 
June 2023
Harmonized Pediatric Lipid Reporting Recommendations for Clinical Laboratories
Presentation Type: Poster
Conference Name/Location: Annual Conference of the Canadian Society of Clinical Chemists (CSCC). Winnipeg MB, Canada
Authors: Higgins V, White-Al Habeeb N, Venner AA, Bailey D, Beriault DR, Collier C, Blasutig I, Adeli K
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_2023_poster.pdf
 
May 2023
Harmonized Pediatric Lipid Reporting Recommendations for Canadian Clinical Laboratories
Presentation Type: Poster
Conference Name/Location: American Association of Clinical Chemistry (AACC) Rocky Mountain Local Section Spring Meeting. Albuquerque, NM, USA
Authors: Higgins V, White-Al Habeeb NMA, Venner AA, Bailey D, Beriault DR, Collier C, Blasutig IM, Adeli K
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_adlm_rocky_mountain_2023_poster.pdf
 
June 2022
Harmonized Lipid Reporting for Clinical Laboratories based on the 2021 Canadian Cardiovascular Society Lipid Guidelines
Presentation Type: Roundtable
Conference Name/Location: Annual Conference of the Canadian Society of Clinical Chemists (CSCC). Niagara Falls ON, Canada
Authors: White-Al Habeeb N, Higgins V, Venner AA, Bailey D, Beriault DR, Collier C, Adeli K
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_2022_roundtable.pdf
 
January 2021
Harmonized lipid reporting across Canada: CSCC Working Group Recommendations
Presentation Type: Oral
Conference Name/Location: CSCC Education Roundtable
Author: Higgins V
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_education_roundtable_2021_oral.pdf
 
June 2019
Harmonized lipid reporting across Canada: Current variability and proposed harmonized lipid report
Presentation Type: Poster
Conference Name/Location: Annual Conference of the Canadian Society of Clinical Chemists (CSCC). St. John NB, Canada
Authors: Higgins V, White-Al Habeeb N, Bailey D, Venner AA, Collier C, Asgari S, Balion C, Bohn MK, Cembrowski G, Cosme J, Dalton J, Higgins T, Macri J, Seccombe D, Shaw J, Stemp J, Taher J, Adeli K
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_2019_poster.pdf
 
June 2019
Harmonized Lipid Reporting in Canada: One Step Closer
Presentation Type: Roundtable
Conference Name/Location: Annual Conference of the Canadian Society of Clinical Chemists (CSCC). St. John NB, Canada
Authors: White-Al Habeeb N
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_2019_roundtable.pdf
 
November 2018
Harmonized Lipid Reporting Recommendations: An update from the CSCC Working Group on Reference Interval Harmonization
Presentation Type: Oral
Conference Name/Location: OSCC Annual Scientific Meeting. London ON, Canada
Author: Higgins V
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_oscc_2018_oral.pdf
 
June 2018
Harmonized lipid profile assessment and interpretation in Canada
Presentation Type: Roundtable
Conference Name/Location: Annual Conference of the Canadian Society of Clinical Chemists (CSCC). Ottawa ON, Canada
Author: Higgins V
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_2018_roundtable.pdf
 
June 2018
Lipid reporting across Canada: current variability and proposed harmonized lipid profile and interpretive comments
Presentation Type: Poster
Conference Name/Location: Annual Conference of the Canadian Society of Clinical Chemists (CSCC). Ottawa ON, Canada
Authors: White-Al Habeeb N, Higgins V, Bailey D, Venner AA, Agbor T, Asgari S, Balion C, Cembrowski G, Collier C, Cosme J, Dalton J, Fung AWS, Higgins T, Ivica J, Leung F, Macri J, Parker M, Sarfaraz O, Seccombe D, Shaw J, Simons J, Stemp J, Taher J, Truong D, Uddayasankar U, Adeli K
https://cscc-sccc.ca/wp-content/uploads/hri_lipid_cscc_2018_poster.pdf