Speaker #1:
Ka Hang Brian Lam. university of california los angeles.
A suspected case of carbon monoxide poisoning consistent with fentanyl toxicity.
Overview:
This lecture will describe a case of fentanyl poisoning that was with carbon monoxide poisoning.
Objectives:
At the conclusion of this session, participants will be able to:
- Understand the clinical presentation of fentanyl toxicity
- Understand the difference between a traditional opiate immunoassay method and a syntheticfentanyl opioid immunoassay method
Speaker #2:
Lawrence de Koning. Associate Professor and Clinical Biochemist. University of Calgary, Alberta Precision Laboratories and Alberta Children’s Hospital.
Dr. Lawrence de Koning completed a PhD in Health Research Methodology from McMaster University in 2009, and concurrent postdoctoral fellowships in nutritional epidemiology and clinical chemistry at Harvard University from 2009-2012. He became board certified by the American Board of Clinical Chemistry in 2013 and a fellow of the Canadian Academy of Clinical Biochemistry in 2015. Dr. de Koning works as a pediatric clinical biochemist at Alberta Children’s Hospital, a consultant clinical biochemist for Rockyview General Hospital and has numerous clinical and research interests including biomarkers and epidemiology of pediatric and perinatal conditions, laboratory quality improvement, cardiovascular disease, and nutrition.
Overview:
This session will review a case of repeatedly elevated plasma ammonia levels in an adolescent girl which were caused by specimen platelet contamination. Topics covered will include ammonia metabolism, urea cycle disorders, ammonia analysis, and the many preanalytical causes of elevated ammonia and how to minimize them.
Objectives:
At the conclusion of this session, participants will be able to:
- Describe the metabolism of ammonia
- Understand the clinical manifestations of urea cycle disorders and appropriate treatments
- Cite a number of common preanalytical causes for elevated ammonia, and identify ways to prevent them
Speaker #3:
Andre Mattman, MD, FRCPC. Medical Biochemist. St Paul’s Hospital Chemistry Laboratory / Vancouver General Hospital Adult Metabolic Diseases Clinic.
- Division Head Chemistry Lab St Paul’s Hospital, Vancouver, BC since 2019
- Physician consultant Adult Metabolic Diseases Clinic, Vancouver General Hospital since 2006.
- Member of the multiple physicians and the environmental groups including Doctors for Planetary Health and the Royal College of Canada working group on CanMeds 2025 Planetary Health competencies.
- Past Chair Royal College of Canada National subspecialty committee in medical biochemistry.
Overview:
Three cases of oxalate nephropathy will be reviewed. Oxlate nephropathy may be caused by primary and secondary etiologies . The investigation of oxalate nephropathy is complicated by the impact of nephropathy on oxalate concentrations in blood and urine. Nonetheless, oxalate nephropathy is responsive to etiology specific therapy – in some cases readily responsive – and so the laboratory’s role in documenting the etiology is an important piece of patient recovery.
Objectives:
At the conclusion of this session, participants will be able to:
- Identify the common causes of acquired oxalate nephropathy.
- Recognize that there are primary hyperoxaluria conditions which have distinct gene specific treatments (that area also distinct as compared to the acquired causes).
- Identify the laboratory tests of utility in diagnosing primary and secondary hyperoxaluria