Speaker:
Josh Raizman, Alberta Precision Labs.
Dr. Josh Raizman is a clinical biochemist with Alberta Precision Labs and Associate Clinical Professor in the department of Laboratory Medicine and Pathology at the University of Alberta. He supports Special Chemistry testing at the University of Alberta Hospital and core chemistry laboratories at regional tertiary hospital centres. One of his interests is involving undergraduate students in hands on laboratory projects, then applying this work to solve laboratory problems. This is exemplified in the work being presented today.
Overview:
Hydroxocobalamin (OHCob), a form of vitamin B12 and mar keted as Cyanokit , is commonly used as an antidote for cyanide poisoning in patients with smoke inhalation injuries. OHCob imparts a red hue to plasma and urine and can take over a week to be cleared from circulation. Work from our laboratory has shown that OHCob interferes with many assays and is analyzer-dependent. This presentation will highlight interference studies and demonstrate strategies used to mitigate, identify, and report these samples. Interdisciplinary collaboration between the laboratory, clinicians, and pharmacists is crucial to develop laboratory protocols on OHCob interferences.
Objectives:
At the conclusion of this session, participants will be able to:
- Describe the use of hydroxocobalamin (OHCob) and its impact on laboratory tests.
- Identify specific analyzers and tests that are affected by OHCob interference.
- Apply strategies for mitigating interference, identifying samples, and reporting results.
- Practice interdisciplinary collaboration between the laboratory, clinicians, and pharmacists to provide solutions for OHCob interference challenges.